Probably an antivirus program is blocking attempts to change the home page.
If you are using Norton Internet Security, turn this off by:
1. Open Norton Internet Security
2. Click Options, select Norton Antivirus
3. Under Internet, click Home Page Protection
4. Uncheck Turn Home Page Protection On

Other systems are probably similar.

"Russone" wrote:

> No matter what I change, MSN, a few minutes later, is again my default IE7
> homepage. Help?
> --
> Russone